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| Wednesday, September 15th , 2021 |
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| RP Travis Salopek was designated for assignment. |
| Tuesday, September 7th , 2021 |
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| SP Jerry Bowman was designated for assignment. |
| Friday, August 13th , 2021 |
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| SP Aaron Daniels was designated for assignment. |
| Tuesday, June 22nd , 2021 |
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| RP Rob Harvey was designated for assignment. |
| Thursday, June 10th , 2021 |
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| SP Micah Gibson was designated for assignment. |
| Friday, February 26th , 2021 |
|---|
| Promoted RP Jordan Clayton to American Baseball Association Indianapolis. |
| Promoted RP Danny Gonzales to American Baseball Association Indianapolis. |
| Promoted RP Brad Bixby to American Baseball Association Indianapolis. |
| Promoted CL Casey Odom to American Baseball Association Indianapolis. |
| Promoted RP Justin Brownlee to American Baseball Association Indianapolis. |
| Promoted RP Vince Rice to American Baseball Association Indianapolis. |
| Promoted 2B Marcos Santiago to American Baseball Association Indianapolis. |
| Promoted 1B Fred Noffz to American Baseball Association Indianapolis. |
| Promoted RP Mike Canales to American Baseball Association Indianapolis. |
