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| Sunday, November 27th , 2022 |
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| Kalamazoo Comets: Signed Manager Morgan Van Dyke. |
| Friday, November 18th , 2022 |
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| White Deer Tropics: Signed Manager Brendan Rees. |
| Thursday, November 10th , 2022 |
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| Deltaville Deltas: Signed Manager Edgar Hernandez. |
| Tuesday, November 1st , 2022 |
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| St. Catharines Blue Jays: CF Jesus Rodriguez retired from professional baseball. |
| Tampa Capitals: RP Lupe de Rojas retired from professional baseball. |
| Newark Flyers: Pitching Coach Josh Marino retires. |
| Columbus Bowsers: Hitting Coach Alex Gutierrez leaves the team, his contract was not renewed |
| Cottage City Cannonballers: Pitching Coach Travis Fedora leaves the team, his contract was not renewed |
| Long Beach Keys: Manager Blake Barber leaves the team, his contract was not renewed |
| Louisville Sweepers: Hitting Coach Jerry Martinez leaves the team, his contract was not renewed |
| Lake Elsinore Storm: Pitching Coach Ryan Stout leaves the team, his contract was not renewed |
| Lake Elsinore Storm: Hitting Coach Manny Garvey leaves the team, his contract was not renewed |
| White Deer Tropics: Pitching Coach Keith Young leaves the team, his contract was not renewed |
| White Deer Tropics: Hitting Coach Carlos Escalera leaves the team, his contract was not renewed |
| White Deer Tropics: Manager Wil Olivares leaves the team, his contract was not renewed |
| Deltaville Deltas: Hitting Coach Dave Hendrickson leaves the team, his contract was not renewed |
| Weedpatch Widowmakers: Pitching Coach Andrew Bower leaves the team, his contract was not renewed |
| Weedpatch Widowmakers: Hitting Coach Heriberto Salgado leaves the team, his contract was not renewed |
| Newark Flyers: Activated RF Fernando Angulo from the injured list. |
| Newark Flyers: Appointed Francisco Ortiz as Pitching Coach. |
| Newark Flyers: Appointed Matt Conners as Manager. |
| Newark Flyers: Appointed Chase Hahn as Hitting Coach. |
| Monday, October 31st , 2022 |
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| Newark Flyers: Signed Hitting Coach Ruben Vinas to a 2-year contract extension. |
| Saturday, October 29th , 2022 |
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| Cottage City Cannonballers: Signed Manager Justin Eaglin. |
| Wednesday, October 12th , 2022 |
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| Poplar Bluff Hillbillies: Signed - Adrian Mercado to a 1-year contract extension. |
| Thursday, October 6th , 2022 |
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| Dollywood Partons: SP Kevin McRoberts retired from professional baseball. |
| Grand Rapids Jet Hawks: 1B Antonio Sauceda retired from professional baseball. |
| San Antonio Stallions: SS Tyler Rawlings retired from professional baseball. |
| Deltaville Deltas: RP Danny Wolf retired from professional baseball. |
| Kalamazoo Comets: Manager Malcolm Griffin retires. |
| Deltaville Deltas: Manager Tony Sarmiento retires. |
| Thursday, September 22nd , 2022 |
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| Newark Flyers: Placed RF Fernando Angulo on the 7-day injured list, retroactive to 09/20/2022. |
| Thursday, August 25th , 2022 |
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| Newark Flyers: Placed RP Nate Ray on the active roster. |
| Tuesday, August 16th , 2022 |
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| Louisville Sweepers: Signed - Steve Reid to a 2-year contract extension. |
| Saturday, August 13th , 2022 |
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| Newark Flyers: Placed RP Nate Ray on the 7-day injured list, retroactive to 08/10/2022. |
| Newark Flyers: Released SP Kevin Irons. |
| Bangor Lumberjacks: Released C Mark Rivera. |
| Bangor Lumberjacks: Released 2B Bobby Scheffel. |
| Sunday, July 31st , 2022 |
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| Bangor Lumberjacks: Released RP Joe Love. |
| Bangor Lumberjacks: Placed LF Skyler Fundis on the active roster. |
| Tuesday, June 28th , 2022 |
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| Newark Flyers: Released 1B Matt Hutzel. |
| Newark Flyers: Released SS Brent Frankel. |
| Bangor Lumberjacks: Released RP Marco Rodriguez. |
| Bangor Lumberjacks: Released 2B Tony Dunn. |
| Bangor Lumberjacks: Released SS Joe Bos. |
| Wednesday, June 8th , 2022 |
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| Newark Flyers: Released LF Ismael Ornelas. |
| Monday, May 23rd , 2022 |
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| Newark Flyers: Placed 2B Ryan Nielsen on the active roster. |
| Monday, April 25th , 2022 |
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| Atlanta Aggies: Placed RP Victor Montoya on the 7-day injured list, retroactive to 04/22/2022. |
