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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Brian LaFever | 351 | 2003-2018 | |
| 2 | Pat Howe | 316 | 2005-2019 | |
| 3 | David Perdomo | 291 | 2000-2012 | |
| 4 | Adam Nance# | 286 | 2008-2020 | |
| 5 | Jason Brown# | 278 | 2007-2020 | |
| 6 | Luis Soto | 275 | 2005-2017 | |
| 7 | Rogelio Sanchez | 239 | 2001-2016 | |
| 8 | Dan Walker | 225 | 2001-2015 | |
| 9 | C.J. Sidney | 219 | 2000-2010 | |
| 10 | Andrew DeGroff | 217 | 2000-2010 | |
| 11 | Willie Granados | 215 | 2000-2010 | |
| 12 | Andre Cunningham | 194 | 2008-2019 | |
| 13 | Kevin Iskra | 192 | 2010-2019 | |
| 14 | Rodolfo Alvarez | 187 | 2000-2008 | |
| 15 | J.R. Pohlman | 184 | 2000-2008 | |
| 16 | Joel Harrison | 169 | 2001-2017 | |
| 17 | Johnny Ortega | 162 | 2000-2016 | |
| 17 | Jeremy Yamakawa | 162 | 2005-2020 | |
| 19 | Danny Cruz | 156 | 2000-2011 | |
| 20 | Mitch Philipp# | 142 | 2013-2020 | |
| 21 | Chris Beasley# | 134 | 2016-2021 | |
| 22 | Jim Mireles | 120 | 2007-2015 | |
| 23 | Joham Fafes | 111 | 2004-2014 | |
| 24 | Bobby Mendoza# | 105 | 2018-2021 | |
| 24 | Julio Ramirez | 105 | 2003-2014 | |
| 26 | Mike Thompson# | 104 | 2014-2021 | |
| 27 | Clark Owens# | 102 | 2018-2021 | |
| 28 | Josh Miller | 95 | 2000-2013 | |
| 29 | Steve Wooldridge# | 93 | 2018-2021 | |
| 30 | Jon Atwell | 92 | 2009-2019 | |
| 30 | Mitchell Young | 92 | 2000-2007 | |
| 32 | Sean Drummond | 90 | 2000-2007 | |
| 32 | Ernesto Ramirez# | 90 | 2017-2021 | |
| 34 | Luis Pompa# | 88 | 2012-2019 | |
| 35 | Danny Solis# | 86 | 2008-2019 | |
| 36 | Tsunemi Higaki | 84 | 2007-2016 | |
| 37 | Caleb Strouse | 83 | 2000-2014 | |
| 38 | George Dashiell | 82 | 2000-2009 | |
| 39 | Jeremy Moore# | 81 | 2014-2020 | |
| 40 | Russ Bansemer | 80 | 2010-2019 | |
| 41 | Matt Lawson# | 77 | 2017-2021 | |
| 42 | Matt O'Brien | 75 | 2000-2006 | |
| 43 | Eric Bradstreet# | 72 | 2016-2021 | |
| 44 | Juan Lopez | 71 | 2012-2018 | |
| 45 | Ian McKibbins# | 67 | 2019-2021 | |
| 46 | David Dutton | 66 | 2004-2015 | |
| 47 | Miles Hayes | 64 | 2000-2012 | |
| 47 | Jon Pitts# | 64 | 2014-2021 | |
| 49 | Jay Thibodeaux# | 61 | 2014-2021 | |
| 50 | Aharon Kroyan# | 59 | 2019-2021 | |
| 51 | David Atchley | 58 | 2008-2016 | |
| 51 | Chao-yang Shui | 58 | 2002-2008 | |
| 53 | Alfonso Alvarez# | 57 | 2013-2019 | |
| 53 | Vince Austin# | 57 | 2015-2019 | |
| 53 | Chris Cocks | 57 | 2005-2011 | |
| 56 | Justin LaMontagne# | 55 | 2014-2016 | |
| 56 | Gabriel Perez | 55 | 2006-2018 | |
| 56 | Josh Terrien# | 55 | 2017-2021 | |
| 56 | Tom Tillotson | 55 | 2007-2016 | |
| 60 | Dan Brewer# | 54 | 2018-2021 | |
| 60 | Tadao Kitagawa | 54 | 2001-2010 | |
| 60 | David Maynard | 54 | 2006-2013 | |
| 63 | Joe Engle | 53 | 2012-2018 | |
| 64 | Jose Duarte# | 50 | 2018-2020 | |
| 65 | John Jones | 48 | 2000-2003 | |
| 66 | Dustin Houston | 47 | 2006-2016 | |
| 67 | Jonathan Rivera | 46 | 2010-2018 | |
| 68 | Mike Melin# | 44 | 2015-2020 | |
| 69 | Josh Spencer# | 43 | 2016-2021 | |
| 70 | Jason Armstrong | 42 | 2009-2018 | |
| 70 | German Galvan | 42 | 2014-2017 | |
| 70 | Derek Maher# | 42 | 2019-2021 | |
| 73 | Matt Liebler# | 41 | 2015-2020 | |
| 74 | Ramon Hernandez | 40 | 2002-2014 | |
| 75 | Steve Ausman | 39 | 2008-2019 | |
| 75 | Vance West | 39 | 2010-2017 | |
| 77 | Jimmy MacDonald# | 38 | 2017-2021 | |
| 78 | Quincy Cook# | 37 | 2012-2020 | |
| 78 | Enrique Islas# | 37 | 2013-2020 | |
| 78 | Jon Wagner# | 37 | 2019-2021 | |
| 81 | Jonathan Ashley# | 36 | 2004-2021 | |
| 82 | Emilio Abreu# | 35 | 2012-2021 | |
| 82 | Adam Staley | 35 | 2000-2008 | |
| 84 | Jesus Lopez | 34 | 2008-2015 | |
| 85 | Bert Covey | 33 | 2000-2007 | |
| 85 | Roger Laib | 33 | 2007-2018 | |
| 85 | Chad Meador | 33 | 2007-2013 | |
| 85 | Nick Pratt# | 33 | 2014-2021 | |
| 85 | Nick Stephens | 33 | 2008-2014 | |
| 90 | Josh Hazeltine# | 32 | 2016-2020 | |
| 91 | Ricardo Herrera# | 31 | 2019-2020 | |
| 91 | Ângelo Sedas# | 31 | 2012-2020 | |
| 93 | Chris Harruff | 30 | 2011-2017 | |
| 93 | Jose Torres | 30 | 2000-2006 | |
| 95 | Ville Hinkkanen# | 29 | 2017-2020 | |
| 96 | Gus Marquez# | 28 | 2019-2020 | |
| 97 | Tony Ochoa# | 27 | 2012-2021 | |
| 97 | Mike Pardo# | 27 | 2016-2020 | |
| 97 | Ernesto Villagomez# | 27 | 2015-2018 | |
| 100 | Justin Cross# | 26 | 2017-2020 |
