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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Antonio Higuera# | 349 | 2007-2021 | |
| 2 | Eric Burdine | 333 | 2000-2017 | |
| 2 | Geremia Farinelli | 333 | 2000-2014 | |
| 4 | Heriberto Milan# | 313 | 2007-2021 | |
| 5 | Chad Landreth | 306 | 2001-2017 | |
| 6 | Jordan Clarke# | 290 | 2004-2021 | |
| 7 | Corey Gruver# | 287 | 2006-2021 | |
| 7 | Jonathan Luna | 287 | 2000-2011 | |
| 9 | David Nations | 283 | 2000-2008 | |
| 10 | Vance Adams | 281 | 2000-2013 | |
| 11 | Xiang-ling Fei* | 273 | 2000-2012 | |
| 12 | Tony Lopez# | 265 | 2013-2021 | |
| 13 | William Arredondo | 263 | 2000-2012 | |
| 14 | Miles Hale | 261 | 2000-2011 | |
| 15 | Kyle Ziegler | 259 | 2000-2011 | |
| 16 | Jose Alvarado | 257 | 2006-2016 | |
| 17 | Greg Sandlin# | 255 | 2009-2021 | |
| 18 | Brian Chambliss | 252 | 2000-2014 | |
| 19 | Chris McLure | 250 | 2000-2010 | |
| 20 | Tyrone Hairston | 248 | 2002-2013 | |
| 21 | Brian Rohde | 239 | 2009-2020 | |
| 22 | Edwin Gutierrez | 235 | 2000-2010 | |
| 23 | Sean Bartol | 232 | 2000-2010 | |
| 24 | Paul Ledford* | 230 | 2000-2013 | |
| 25 | Russ Allen | 228 | 2000-2012 | |
| 25 | Jose Moreno | 228 | 2000-2014 | |
| 27 | Du-sung Moon | 227 | 2002-2015 | |
| 28 | Gates Callaghan | 224 | 2004-2014 | |
| 28 | Barry McLamb# | 224 | 2013-2021 | |
| 30 | Pat Gonzalez | 222 | 2000-2013 | |
| 31 | Tony Figueroa# | 219 | 2014-2021 | |
| 32 | Bobby Dodd | 217 | 2005-2016 | |
| 32 | Nick Mathiesen | 217 | 2000-2010 | |
| 34 | Seth Carey | 216 | 2004-2016 | |
| 35 | Iliana Preciado | 212 | 2000-2009 | |
| 36 | Hiromi Fukuda | 210 | 2006-2018 | |
| 37 | Tom Kitko# | 208 | 2012-2021 | |
| 38 | Cody Morosko | 207 | 2000-2010 | |
| 39 | Eric Angelone | 205 | 2004-2013 | |
| 40 | Hector Ruiz | 203 | 2001-2013 | |
| 40 | Bill Vasquez | 203 | 2000-2012 | |
| 42 | Nick Lawson | 199 | 2002-2017 | |
| 42 | Brian Prince# | 199 | 2011-2021 | |
| 44 | Octavio Ruiz | 198 | 2000-2011 | |
| 45 | Felipe Gonzalez# | 197 | 2011-2020 | |
| 46 | Tony Marcano | 195 | 2000-2011 | |
| 46 | J.R. Mitchell# | 195 | 2013-2021 | |
| 48 | Casey Abbott# | 194 | 2009-2021 | |
| 49 | Rogelio Aburto | 192 | 2009-2020 | |
| 50 | Tommy Bressette | 188 | 2000-2009 | |
| 51 | Chris Kuperman | 186 | 2002-2012 | |
| 51 | Jorge Lopez | 186 | 2004-2013 | |
| 53 | Jeremy Hewes# | 184 | 2010-2021 | |
| 53 | Andy Shoemaker# | 184 | 2012-2021 | |
| 55 | Seth Dann | 183 | 2002-2013 | |
| 55 | Ching Ding | 183 | 2000-2009 | |
| 55 | Noah George | 183 | 2005-2017 | |
| 55 | Jeff Glissman | 183 | 2000-2010 | |
| 59 | Albert Fabian# | 182 | 2014-2021 | |
| 59 | Alfredo Tiscareno# | 182 | 2010-2021 | |
| 61 | Sukeaki Kato | 179 | 2001-2014 | |
| 61 | Carlos Mendez# | 179 | 2011-2021 | |
| 63 | Chris Harris | 176 | 2007-2020 | |
| 64 | Julio Melendez | 175 | 2000-2012 | |
| 65 | Alex Dopico | 172 | 2000-2009 | |
| 66 | Alex Alvarez# | 171 | 2010-2019 | |
| 67 | Jeff Rochefort# | 170 | 2009-2019 | |
| 68 | Tim Ward | 169 | 2000-2009 | |
| 69 | Elard Nijhuis | 168 | 2000-2009 | |
| 70 | Byung-sik Lee | 167 | 2006-2014 | |
| 70 | Chris Mattison# | 167 | 2012-2019 | |
| 70 | Keith Young | 167 | 2000-2007 | |
| 73 | Zachary Christman# | 166 | 2014-2021 | |
| 73 | Chris Shifflett | 166 | 2004-2014 | |
| 73 | Nate Simons | 166 | 2003-2012 | |
| 76 | Willie Sanchez | 164 | 2000-2011 | |
| 76 | Ruben Ulloa | 164 | 2000-2008 | |
| 78 | Tomas Adon | 163 | 2004-2018 | |
| 78 | David Jacquez | 163 | 2000-2011 | |
| 80 | Ryan DeVault | 162 | 2007-2015 | |
| 80 | Danny Freeman | 162 | 2001-2010 | |
| 80 | Travis Thurber# | 162 | 2005-2021 | |
| 83 | Ray Stanberry | 160 | 2000-2007 | |
| 84 | Javy Mendoza | 158 | 2000-2010 | |
| 84 | Bobby Moreno | 158 | 2005-2014 | |
| 84 | Bill Rauch# | 158 | 2011-2021 | |
| 87 | Rusty Hays | 157 | 2000-2009 | |
| 88 | Blake Barber | 156 | 2000-2007 | |
| 88 | Jonathan Higginbotham# | 156 | 2010-2021 | |
| 88 | Adrian Radecki# | 156 | 2012-2019 | |
| 88 | Joe Young | 156 | 2000-2005 | |
| 92 | Jonathan Gonzales# | 155 | 2012-2021 | |
| 92 | Joe Wills# | 155 | 2016-2021 | |
| 94 | Nick Hawks | 154 | 2001-2012 | |
| 94 | John Way# | 154 | 2016-2021 | |
| 96 | Marcos Cerda# | 153 | 2013-2019 | |
| 96 | Adam Webb | 153 | 2007-2015 | |
| 98 | Jim Clarke | 152 | 2000-2014 | |
| 98 | Travis Gross# | 152 | 2014-2021 | |
| 98 | Andres Moran# | 152 | 2011-2021 |
