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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Corey Cawley# | 19 | 2021 | |
| 2 | Jerry Robinson# | 13 | 2021 | |
| 2 | Joe Chennault# | 13 | 2021 | |
| 2 | Sam Salas# | 13 | 2021 | |
| 5 | Tyler Tolbert# | 12 | 2021 | |
| 6 | Billy Totten# | 10 | 2021 | |
| 6 | Dale Day# | 10 | 2021 | |
| 8 | Chris Scoville# | 9 | 2021 | |
| 9 | Brian Phillips# | 8 | 2021 | |
| 10 | Jerry Blake# | 7 | 2021 | |
| 10 | Luis Casanova# | 7 | 2021 | |
| 12 | Jason Perrigin# | 6 | 2021 | |
| 13 | Justin Wish# | 5 | 2021 | |
| 14 | Carlos Quintana# | 4 | 2021 | |
| 15 | Keith Tarrant# | 3 | 2021 | |
| 15 | Jason Paulsen# | 3 | 2021 | |
| 15 | William King# | 3 | 2021 | |
| 15 | Rogelio Lopez# | 3 | 2021 | |
| 19 | Rafael Silva# | 2 | 2021 | |
| 19 | Miguel Cerpa# | 2 | 2021 | |
| 19 | Chris Sutherland# | 2 | 2021 | |
| 22 | Willie de Leon# | 1 | 2021 | |
| 22 | T.J. Parker# | 1 | 2021 | |
| 22 | Edwin Arroyo# | 1 | 2021 |
